Tramadol vs. Oxycodone: main differences and similarities

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Tramadol vs. Oxycodone: main differences and similarities

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Oxycodone is a semi-synthetic narcotic, opioid pain management technique. It is derived from a part of a poppy plant called thebaine.

Tramadol is a synthetic opioid narcotic-like analgesic. It is not a narcotic medication like Oxycodone.

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The initial FDA-approved doses of Tramadol begin at Tramadol 25mg to 50mg, which can be increased to Tramadol 100mg. Tramadol dose that is not approved by the FDA is Tramadol 225mg in the USA and 200mg.

Oxycodone is a strong μ-opioid receptor
agonist, quite similar in analgesic potency to morphine, and it is used orally for cancer pain and for post-operative pain.

Tramadol 225mg in usa , a weak opioid μ-receptor agonist, may have a favorable potency and side effect profile for intravenous patient-controlled analgesia (PCA).

Tramadol is a centrally-acting pain killer drug with a low affinity for μ-opioid receptors. Tramadol is as low as 1/6 to 1/10 as potent an analgesic as morphine when both intensity and duration of the effect were considered.

The low risk of respiratory depression makes it potentially suitable for analgesic use with PCA, which is a popular method for postoperative pain management.

Oxycodone is a Schedule II drug as classified in the Controlled Substance Act of the FDA.

Tramadol is a schedule IV drug as classified in the Controlled Substance Act of the FDA.

Tramadol has a lower possibility of abuse and drug dependence than that of Oxycodone.

Tramadol and Oxycodone are effective pain management techniques to treat moderate to severe, chronic and acute pain.

Both drugs share some common side effects
that include:

Common side effects of Oxycodone and Tramadol
include:

•        Constipation

•        Headache

•        Sweating

•        Dizziness

•        Dry mouth

Tramadol has lesser side effects and
withdrawal symptoms as compared to Oxycodone if administered in lower doses for a short term and as prescribed.

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Some side effects and adverse effects are
different for Oxycodone and Tramadol.

Oxycodone should be carefully used under a
doctor’s guidance for elderly, debilitated patients, and patients suffering from severe lung diseases. In these cases, it depresses breathing. Some patients who administered Tramadol had seizures.

Both Oxycodone and Tramadol are addictive and habit-forming. Patients may become drug dependent and drug seekers.

If stopped abruptly both drugs cause withdrawal symptoms. Some common withdrawal symptoms of both drugs include:

•        Anxiety

•        Nausea

•        Vomiting

•        Diarrhea

•        Tremors

•        Hallucinations

•        Rigor

•        Pain

•        Insomnia

Oxycodone has been reported for several drug interactions. It should never be mixed with alcohol, barbiturates, muscle relaxants, or benzodiazepines like Alprazolam or its brand Xanax, as it will cause severe side and dangerous adverse effects. Several other drug interactions occur with Oxycodone.

Tramadol also has several drug interactions, for example, Tramadol interacts with monoamine oxidase inhibitors (MAOI), or (selective serotonin inhibitors (SSRI), for example, fluoxetine (Prozac).

The safety of Oxycodone and Tramadol has not been established. Children born to mothers who were taking Oxycodone for a prolonged period of time may suffer side effects.

Oxycodone is secreted in breast milk in small amounts, so it may cause side effects in the newborn. The safety of Tramadol in breastfeeding women has not been established.


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